Services
From a written target assessment to candidate design and agreed testing. Omics analysis, model training and application building can also be commissioned independently.
Assessment, design and testing form the binder-development route. Omics, modelling and applications extend it where your question needs them. Each service has agreed deliverables, with one contract and one contact at InXBio.
By us, in silicoThrough a partner laboratory
Data analysis and modelling
Protein assessment and design
Measurements and scientific applications
Binder tests and proteomics feed the next round
By us, in silico
You have data and a question: your own measurements, public data sets, or both. We work with protein and sequence data first, and with patient data where the question needs it. We compare conditions, integrate omics layers, analyse networks, and select targets by functional analysis. No laboratory is involved.
No data yet? A partner laboratory measures your samples: Proteomics measurement.
Published
A comparison, as it is usually first looked at.
The same proteins against a prediction score: what is worth the bench.
The same proteins placed by similarity, where a change often sits together.
The same proteins as a network: which of them interact, and which way each one moved.
What it covers
By us, in silico
We train and evaluate machine-learning and deep-learning models on protein sequences, structures and structural models, experimental measurements, proteomics tables and patient data, combining these sources where useful. We use explainable AI (XAI) to identify features that support a prediction; our published CPP study on γ-secretase substrates is one example. We evaluate against baselines suited to your question and use protein language models where they benefit the task.
Published
What it covers
By us, in silico
A bounded first engagement: we review your target, its biological context, candidate binding sites and the evidence available for testing. The assessment records uncertainties and recommends whether to proceed, obtain more evidence or use another approach.
Scope, price and any assessment credit are agreed in your quotation. See how to order.
What it covers
By us, in silico
Candidates designed against the agreed site, assessed computationally for structure and predicted cross-reactivity, then ranked with their selection rationale. You review the candidate set and construct plan before synthesis.
Making and testing the binders is a service of its own: Production and testing.
Further reading
What it covers
Through a partner laboratory
The binders you approved are produced and their binding is measured, in the assay format you declared. A partner laboratory does the bench work. We select it for your assay, coordinate it, and report against the criteria agreed up front.
What is measured is set out in the release specification.
Through a partner laboratory
A partner laboratory measures your samples by mass spectrometry. We agree the study question and coordinate measurement; data analysis is commissioned with us. Binder-associated proteins can be investigated where an appropriate experimental study is agreed.
The analysis is our own work, and the start of the next round: Omics data analysis.
Published, on measurement quality
By us, in silico
We build scientific applications around your data and the decisions your team needs to make. The scope can range from a standalone HTML tool to an application hosted by InXBio or deployed on your own server.
Try an example: Membrane Annotation →
This is software built for your project. Our own software is described under Platform.
Software we have published
What it covers
Where it runs
We are still contracting our partner laboratories and name them per project.
This is where the services combine, and because each stage carries its own acceptance criteria, a project can be commissioned one stage at a time and stopped where the evidence stops.
Each stage has one objective and groups the services needed to reach it.
One-stage project
The target and its structure are known. Assessment, design and experimental testing form one stage with a single objective: a binder that detects the protein.
Two-stage project
Where the epitope has to be found first, a prediction step comes before the design: here, which position of the amyloid precursor protein a protease cuts.
Three-stage project
Two binders against two different targets, coupled through a designed linker whose length and rigidity set the geometry of the pair.
Illustrative project examples. The structures show possible project shapes, not experimental results.
Start with a free consultation to define the question. The paid assessment then returns a written feasibility recommendation. Design, production and testing proceed only within the scope, budget and acceptance criteria agreed for your project.
Not sure whether a binder is the right tool, or which site to aim at? We talk through the target and the experiment, and whether an assessment makes sense.
A written judgement on the target and the site. Your quotation sets out the scope, budget, any assessment credit and follow-up work.
Candidates against the agreed site, counter-screened against the proteins you named and ranked with the reasons for the ranking.
You see the shortlist and the construct plan. Nothing is made until you approve them.
Partner laboratories produce the selected binders and measure binding, in the assay format you declared.
A report against the criteria agreed up front, static or interactive, with the measurement context and any binders that met them. An application can be built on it, and we take part in writing the paper if you want one.
What we ask in the call
Missing answers are fine. Finding them is often the first deliverable.
Where a binder can aim
The assessment names the site. Example: a seven-pass receptor, where only the loops outside the cell can be reached.
From the site to a shortlist
Illustrative workflow. The steps are chosen for the target and the assay.
You choose what is made
| Design | Interface | Fold | PD-L2 risk | Test? |
|---|---|---|---|---|
| bnd-014 | 0.82 | 0.88 | low | ✓ |
| bnd-031 | 0.79 | 0.91 | low | ✓ |
| bnd-022 | 0.77 | 0.85 | low | ✓ |
| bnd-006 | 0.91 | 0.74 | high | – |
Illustrative predictions. The highest-scoring example is excluded because of predicted cross-reactivity risk. Testing checks whether that prediction holds.
Made, then measured
Illustrative shapes, not measurements. Which of them is run is set by the assay format you declared, and the numbers go into the release record.
Release record
What the report contains, against the criteria agreed before the work started.
We quote privately per project, in euro. We work with businesses, institutions and private customers, including institutional purchase orders. A complete campaign has a planning goal of 4 to 7 weeks; materials, assay requirements and laboratory availability determine the agreed schedule.
Assay-ready means material that meets the acceptance criteria agreed for your assay. The record separates computational evidence from laboratory measurements and identifies the methods, conditions and sample used. The table shows the questions each can address; measurements are selected for the project.
| Property | Computational evidence | Experimental measurement |
|---|---|---|
| Binding | Predicted interface and complex confidence | SPR or BLI |
| Aggregation | Predicted aggregation and solubility | Analytical SEC |
| Identity | Expected mass, from the sequence | SDS-PAGE, intact LC-MS |
| Thermal stability | Predicted thermal stability | nanoDSF |
| Specificity | Predicted cross-reactivity against specified relatives | SPR, BLI or ELISA |
| Amount | Sequence-derived extinction coefficient to interpret absorbance | A280, SDS-PAGE |
| Optional: specificity across the proteome | Sequence and structure comparisons to prioritise off-target tests | Pull-down, MS |
A computed value is a prediction, not a measurement. The record shows both.
Which format fits
Antibody, nanobody or minibinder: compare formats for your target and assay.
You get a straight answer about what is realistic.
Research use only. Scope, criteria and deliverables are agreed per project.
